The impact of various types of α-thalassemia on perinatal complications and pregnancy outcomes in pregnant women

作者：Yi Li, Yuanyuan Feng, Yiyun Wei, Jing Huang, Hui Chen, Changqiang Wei, Kaiyi Wei, Lihong Pang · 发表于：Annals of Hematology · 年份：2025 · DOI：10.1007/s00277-025-06287-0 · 被引用次数：3 · 研究领域：Hemoglobinopathies and Related Disorders、Iron Metabolism and Disorders、Pregnancy and preeclampsia studies

This study aims to investigate the adverse effects of different types of α-thalassemia on pregnant women and their differences, so as to provide reference for the prevention and monitoring of perinatal complications in different types of α-thalassemia pregnancy. The observation group comprised 1371 singleton pregnant women with α-thalassemia, control group comprised 680 non-thalassemia singleton pregnancies during the same period. The thalassemia genotypes of the observation group were tallied and categorized based on their respective genotypes within the group. The hemoglobin in the experimental group was lower than control group. The incidences of electrocardiographic abnormality, abnormal liver function, hypertensive disorders, gestational diabetes mellitus and thyroid disorders during pregnancy were higher in the observation group than in the control group. The incidences of preterm labor, caesarean section and postpartum hemorrhage were all higher in the observation group than in the control group. The delivery weight and neonatal hemoglobin in the observation group were lower than those in the control group. Pregnant women with α-thalassemia have more pregnancy and delivery complications than those without α-thalassemia, they should receive more frequent and standardized prenatal examination, so as to find and correct abnormal indicators in time.