Global spatiotemporal dynamics of Mycoplasma pneumoniae re-emergence after COVID-19 pandemic restrictions: an epidemiological and transmission modelling study

作者：Patrick M. Meyer Sauteur, Xu‐Sheng Zhang, Hanne‐Dorthe Emborg, Semjon Sidorov, Sabine Pereyre, Adrien Fischer, Baptiste Lemaire, Gilbert Greub, Petra Zimmermann, Philipp Agyeman, Michael Buettcher, Valeria Gaia, Frank Imkamp, Christoph Berger, Ester Osuna, Beat M Greiter, Benjamin Preiswerk, Silvio D. Brugger, Anita Niederer-Loher, Florence Barbey, Branislav Ivan, Sören L. Becker, Cihan Papan, Johannes Förster, Birgit Henrich, Malik Aydin, Roger Dumke, Claire Brugerolles, Veerle Matheeussen, Mireille van Westreenen, S.F.L. van Lelyveld, Baharak Afshar, Simon Cottrell, Karolina Gullsby, Santtu Heinonen, Miia K. Laine, Henrik Døllner, Danilo Buonsenso, Daniele Dona, Fernanda Rodrigues, Jorge Rodrigues, Federico Martinón‐Torres, Darja Keše, Marija Gužvinec, Katerina Tsantila, Eleni Kalogera, Hila Elinav, Adong Shen, Yaodong Zhang, Jing Bi, Pei Wang, Kunling Shen, Zhengrong Chen, Ki Wook Yun, Hyunju Lee, Mi Seon Han, Tomohiro Oishi, Takeshi Saraya, Tsutomu Yamazaki, Yu‐Chia Hsieh, Tsung-Hua Wu, Matthias Maiwald, Rama Chaudhry, Manish Sadarangani, Larry K. Kociolek, Kami D Kies, Lilliam Ambroggio, Nadia Rodríguez, David Lorenz, Matthew Blakiston, Tsuyoshi Kenri, Ran Nir‐Paz, Cécile Bébéar, Annemarie M. C. van Rossum, Søren Anker Uldum, Michael L. Beeton, Marie Gardette, Noémie Wagner, Alessandra Vitale, René Brouillet, Onya Opota, Christoph Aebi, Irena Mitrović, Marisa Hostettler, Lisa Kottanattu, Marco Bongiovanni, Adrian Egli, Adrian Schibli, Marc Pfister, Günter Dollenmaier, Peter M. Keller, Ulrich Heininger, Sarah Tschudin-Sutter, Colin R. MacKenzie, Nathalie Bossuyt, Marius Vogel, Dennis Souverein, Jayant Kalpoe, Sjoerd M. Euser, Marlies A. van Houten, Marco Goeijenbier, Dominic Snijders, Sendurann Nadarajah, Rebecca Thombre, Anna Lewis, Hannah Bransbury-Hare, Kay-Dee Hosten-Sandy, Kanchanamala Gunasekara, Nita Doshi, Catherine Moore, Ville Peltola, Frode Width Gran, Andreas Christensen, Marilena La Sorda, Giulia Brigadoi, Sara Rossin, Silvia Bressan, Claudia Del Vecchio, Giuseppe Di Pietra, Margarida Farinha, Inês Taborda, Ana Dacosta-Urbieta, Gema Barbeito-Castiñeiras, Goran Tešović, Diana Didović, Arjana Tambić Andrašević, Minos Matsas, Evangelia Petridou, Ioannis Kopsidas, Ayelet Gayego, Wenjian Wang, Qian Hu, Yulei Wang, Xiaojuan Luo, Eun Hwa Choi, Tsutomu Yamazaki, Liat Hui Loo, Tanu Sagar, K. Sreenath, David Goldfarb, Jill Mainella, Jessica Kapinos, Robin Patel, Kelly Pearce, Sam Dominguez · 发表于：The Lancet Microbe · 年份：2025 · DOI：10.1016/j.lanmic.2024.101019 · 被引用次数：53 · 研究领域：Pneumonia and Respiratory Infections、Antibiotic Use and Resistance、Respiratory viral infections research

BACKGROUND: Mycoplasma pneumoniae is a major cause of respiratory tract infections. We aimed to investigate the spatiotemporal dynamics, antimicrobial resistance, and severity of the delayed re-emergence of infections with M pneumoniae after the implementation of non-pharmaceutical interventions (NPIs) against COVID-19. METHODS: Epidemiological data (positive and total test numbers, and macrolide-resistant M pneumoniae detections) and clinical data (hospitalisations, intensive care unit [ICU] admissions, and deaths) were collected through our global surveillance from April 1, 2017 to March 31, 2024. The moving epidemic method (MEM) was used to establish epidemic periods, and the time-series susceptible-infected-recovered (TSIR) model to investigate the delayed re-emergence. FINDINGS: The dataset included 65 sites in 29 countries from four UN regions: Europe, Asia, the Americas, and Oceania. A global re-emergence of M pneumoniae cases by PCR detection was noted from the second half of 2023. The mean global detection rate was 11·47% (SD 15·82) during the re-emergence (April, 2023-March, 2024). By use of MEM, the re-emergence was identified as epidemic in all four UN regions, simultaneously in ten countries at calendar week 40 (early October, 2023). Macrolide-resistant M pneumoniae rates from Europe and Asia were 2·02% and 71·22%, respectively, and did not differ between the re-emergence and pre-COVID-19 pandemic periods. During the re-emergence, some countries reported increase...