Trends in the global, regional, and national burden of oral conditions from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021

作者：Eduardo Bernabé, Wagner Marcenes, Rizwan Suliankatchi Abdulkader, Lucas Guimarães Abreu, Saira Afzal, Fadwa Alhalaiqa, Sadeq Ali Al‐Maweri, Ubai Alsharif, Anayochukwu Edward Anyasodor, Amit Arora, Saeed Asgary, Tahira Ashraf, M. Balasubramanian, Morteza Banakar, Amadou Barrow, Azadeh Bashiri, Sefealem Assefa Belay, Uzma Belgaumi, Alemshet Yirga Berhie, Pankaj Bhardwaj, Sonu Bhaskar, Ali Bijani, Souad Bouaoud, Yin Cao, Akhilanand Chaurasia, Mengxuan Chen, Dinh‐Toi Chu, Natália Martins, Omid Dadras, Xiaochen Dai, Daniel Díaz, Mi Du, Michael Ekholuenetale, Temitope Cyrus Ekundayo, Maha El Tantawi, Muhammed Elhadi, Adeniyi Francis Fagbamigbe, Nima Farshidfar, Ali Fatehizadeh, Florian Fischer, Morẹ́nikẹ́ Oluwátóyìn Foláyan, Piyada Gaewkhiew, Márió Gajdács, Mahaveer Golechha, Bhawna Gupta, Sapna Gupta, Hailey Hagins, Esam S Halboub, Samer Hamidi, Ninuk Hariyani, Simon I Hay, Mohammad Heidari, Brenda Yuliana Herrera-Serna, Demisu Zenbaba Heyi, Sorin Hostiuc, Kyle Matthew Humphrey, Segun Emmanuel Ibitoye, Milena Ilić, Gaetano Isola, Eswar Kandaswamy, Rami S. Kantar, Navjot Kaur, Laura Kemmer, Yousef Khader, Sorour Khateri, Adnan Kısa, Kewal Krishan, Estie Kruger, Ratilal Lalloo, An Li, Stephen S Lim, Tomislav Mestrovic, Ali H. Mokdad, Rafael Silveira Moreira, Shane D. Morrison, Christopher J L Murray, Zuhair S. Natto, Biswa Prakash Nayak, Trang Nguyen, Văn Thành Nguyễn, Abiodun Olusola Omotayo, Alicia Padrón‐Monedero, Jay Patel, Shankargouda Patil, Shrikant Pawar, Ionela-Roxana Petcu, Ibrahim Qattea, Mosiur Rahman, Zubair Ahmed Ratan, Abanoub Riad, S Manjula, S N Chandan, Siamak Sabour, Fatemeh Saheb Sharif‐Askari, Amirhossein Sahebkar, Joseph W. Sakshaug, Abdallah M Samy, Sachin C. Sarode, Monika Sawhney, Falk Schwendicke, Masood Ali Shaikh, Santosh Kumar Tadakamadla, Riki Tesler, Arulmani Thiyagarajan, Marcos Roberto Tovani‐Palone, Muhammad Umair, Bhaskaran Unnikrishnan, Sahel Valadan Tahbaz, Siddhartha Alluri Varma, Ana Vuković, Cong Wang, Nuwan Darshana Wickramasinghe, Lalit Yadav, Arzu Yiğit, Iman Zare, Zhi‐Jiang Zhang, Nicholas J Kassebaum · 发表于：The Lancet · 年份：2025 · DOI：10.1016/s0140-6736(24)02811-3 · 被引用次数：390 · 研究领域：Dental Health and Care Utilization、Oral microbiology and periodontitis research、HIV/AIDS oral health manifestations

BACKGROUND: The WHO Global Oral Health Action Plan has set an overarching global target of achieving a 10% reduction in the prevalence of oral conditions by 2030. Robust and up-to-date information on the global burden of oral conditions is paramount to monitor progress towards this target. The aim of this systematic data analysis was to produce global, WHO region, and country-level estimates of the prevalence of, and disability-adjusted life-years (DALYs) attributed to, untreated caries, severe periodontitis, edentulism, other oral disorders, lip and oral cavity cancer, and orofacial clefts from 1990 to 2021. METHODS: This report is based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021. Input data were extracted from epidemiological surveys, population-based registries, and vital statistics. Data were modelled with DisMod-MR 2.1, a Bayesian meta-regression modelling tool, to ensure consistency between prevalence, incidence, remission, and mortality estimates for oral conditions. DALYs were estimated as the aggregation of the years of life lost (YLLs) due to premature mortality and years lived with disability (YLDs). YLDs were calculated by multiplying prevalence estimates, the severity of the oral condition's sequelae (disability weight) and duration of the sequelae. Although all oral conditions lead to YLDs, only lip and oral cavity cancer and orofacial clefts lead to YLLs as well. 95% uncertainty intervals (UIs) were generated for every metric ...