Simultaneous Construction of Axial and Central Stereogenicity by Cobalt‐Catalyzed Stereoconvergent Reductive Coupling of Heterobiaryl Triflates and Aldehydes

作者：Chuiyi Lin, Xiang Xu, Qinglei Chong, Fanke Meng · 发表于：Chemistry - A European Journal · 年份：2025 · DOI：10.1002/chem.202500248 · 被引用次数：12 · 研究领域：Asymmetric Hydrogenation and Catalysis、Catalytic C–H Functionalization Methods、Axial and Atropisomeric Chirality Synthesis

Catalytic stereoconvergent coupling of racemic heterobiaryl triflates and aldehydes promoted by a readily available chiral cobalt complex is presented. Such processes represent an unprecedented reaction pathway for cobalt catalysis that enable simultaneous construction of axial and central stereogenicity through diastereo- and enantioselective dynamic kinetic transformations and introduction of a chiral fragment onto the heterobiaryl cores without the requirement of preforming stoichiometric amounts of organometallic reagents, affording densely functionalized secondary alcohols in up to 96 % yield, >98 : 2 dr and >99.5:0.5 er. Preliminary investigations on the application of the products demonstrate their potential for serving as a new class of chiral catalysts and ligands. Mechanistic studies suggest that a dynamic kinetic stereoselective process induced by chiral cobalt catalysis is involved.