Early-life growth and emotional, behavior and cognitive outcomes in childhood and adolescence in the EU child cohort network: individual participant data meta-analysis of over 109,000 individuals

作者：Romy Gonçalves, Sophia M. Blaauwendraad, Demetris Avraam, Andrea Beneíto, Marie-Aline A Charles, Ahmed Elhakeem, Joaquín Escribano, Louise Etienne, Gonzalo García-Baquero Moneo, Ana Gonçalves Soares, Jasmin de Groot, Veit Grote, Dariusz Gruszfeld, Kathrin Guerlich, Mònica Guxens, Barbara Heude, Berthold V Koletzko, Aitana Lertxundi, Manuel Lozano, Hanan El Marroun, Rosemary McEachan, Angela Pinot de Moira, Gillian Santorelli, Katrine Strandberg‐Larsen, Muriel Tafflet, Chloe Vainqueur, Elvira Verduci, Martine Vrijheid, Marieke Welten, John Wright, Tiffany Yang, Romy Gaillard, Vincent W. V. Jaddoe · 发表于：The Lancet Regional Health - Europe · 年份：2025 · DOI：10.1016/j.lanepe.2025.101247 · 被引用次数：8 · 研究领域：Infant Development and Preterm Care、Maternal Mental Health During Pregnancy and Postpartum、Health, Environment, Cognitive Aging

Background: Fetal and infant development might be critical for cognitive outcomes and psychopathology later in life. We assessed the associations of birth characteristics and early life growth with behavior and cognitive outcomes from childhood to adolescence. Methods: We used harmonized data of 109,481 children from 8 European birth cohorts. Birth weight, gestational age, and body mass index (BMI) tertiles at the age of 2 years were used as the exposure variables. Outcomes included internalizing and externalizing problems and attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and non-verbal intelligence quotient (Non-verbal IQ) in childhood (4-10 years), early adolescence (11-16 years), and late adolescence (17-20 years). We used 1-stage individual participant data meta-analyses using generalized linear models. Findings: A one-week older gestational age was associated with lower scores for internalizing problems (difference -0·48 (95% CI: -0·59, -0·37)), externalizing problems (difference -0·34 (95% CI: -0·44, -0·23)), and ADHD symptoms (difference -0·38 (95% CI: -0·49, -0·27)), and with higher scores for non-verbal IQ (difference 0·65 (95% CI: 0·41, 0·89)). As compared to term birth, preterm birth was associated with higher internalizing problems (difference 3·43 (95% CI: 2·52, 4·33)) and externalizing problems (difference 2·31 (95% CI: 1·16, 3·46)), ADHD symptoms (difference 4·15 (95% CI: 3·15, 5·16)), ASD symptoms (difference 3·23 (95% CI: 0·...