The properties of TREM1 and its emerging role in pain-related diseases

作者：Zhenzhen Fan, Longde Wang, Songtang Sun, Zhaoming Ge · 发表于：Molecular Brain · 年份：2025 · DOI：10.1186/s13041-025-01187-w · 被引用次数：5 · 研究领域：Inflammation biomarkers and pathways

The TREM1 receptor, a member of the TREMs family, is expressed by myeloid cells and functions as an initiator or enhancer of the inflammatory response, playing a pivotal role in the regulation of inflammation. In recent years, it has been found that TREM1-mediated inflammatory response is involved in the regulation of pain-related diseases. This article provides an extensive review on the structural characteristics and distribution patterns, ligand, signaling pathways, inhibitors, and pathophysiological roles of TREM1 in pain disorders aiming to further elucidate its biological function and offer novel insights for clinical interventions targeting pain-related diseases.