For Better or Worse: Type I Interferon Responses in Bacterial Infection

作者：Aihong Xia, Xin Li, Changjing Zhao, Xiaojing Meng, Gulmela Kari, Yongjuan Wang · 发表于：Pathogens · 年份：2025 · DOI：10.3390/pathogens14030229 · 被引用次数：6 · 研究领域：interferon and immune responses、Immune Response and Inflammation、Inflammasome and immune disorders

Type I interferons (IFNs) are pleiotropic cytokines, primarily comprising IFN-α and IFN-β, and their effect in host defense against viral infection has been extensively studied and well-established. However, in bacterial infection, the role of type I IFNs is more complex, exhibiting multifaceted effects that depend on several factors, such as the pathogen species, the specific cell populations, and the routes of infection. In this review, we summarize research progress on host type I interferon responses triggered by specific bacteria and their immune regulation function in order to better understand the role of type I IFNs in bacterial infection and provide insights for adjuvant therapies tailored to treat specific bacterial infections.