Bacteria-derived 3-hydroxydodecanoic acid induces a potent anti-tumor immune response via the GPR84 receptor

作者：Egle Katkeviciutė, Anna Bircher, Rocío Rivera Sánchez, Martin Schwill, Andrea Dorst, Yasser Morsy, Javier Conde, Nicola Zamboni, Karl Gademann, Michael M. Scharl, Ana Montalban‐Arques · 发表于：Cell Reports · 年份：2025 · DOI：10.1016/j.celrep.2025.115357 · 被引用次数：10 · 研究领域：Gut microbiota and health、Cancer Immunotherapy and Biomarkers、Cancer, Stress, Anesthesia, and Immune Response

T cell infiltration and cytotoxicity within tumor tissue in multiple cancer models. Metabolomics analysis of colorectal cancer patient serum reveals an inverse correlation between the abundance of these metabolites and advanced disease stages. Our findings provide a strong rationale for 3-hydroxydodecanoic acid and the GPR84 receptor to be considered as promising therapeutic targets for cancer treatment.