Organocatalytic Enantioselective Nucleophilic Substitution of Furfurals with Alcohols via a Remote Chiral Control

作者：Chaofan Li, Xinyi He, C.L. Wei, Changxian Yuan, Xiaoqin Shen, Zhiguang Zhang, Bin Cui, Sinan Wang · 发表于：The Journal of Organic Chemistry · 年份：2025 · DOI：10.1021/acs.joc.4c02937 · 被引用次数：1 · 研究领域：Catalysis for Biomass Conversion、Asymmetric Synthesis and Catalysis、Axial and Atropisomeric Chirality Synthesis

We describe herein the direct organocatalytic asymmetric nucleophilic substitution reaction of 2-benzylfurfurals with benzyl alcohols and allylic alcohol in the absence of any metal catalysts and ligands. A series of γ-regioselective products were obtained in high yields and up to 99% enantiomeric excess.