Subcellular targeting strategies: Chemical structure-based design concepts for bioimaging and theranostics

作者：Qihang Ding, Zhiyun Zhang, Mingle Li, Jinghui Zhu, Wenpei Fu, Mengrong He, Ying Bai, Zewei Zhang, Shiying Li, Lin Wang, Cheng Deng, Xuechuan Hong, Yuling Xiao, Jong Seung Kim · 发表于：Cell Biomaterials · 年份：2025 · DOI：10.1016/j.celbio.2024.100001 · 被引用次数：22 · 研究领域：Nanoplatforms for cancer theranostics、Molecular Sensors and Ion Detection、Click Chemistry and Applications

Subcellular structures execute distinct functions within the cell, collectively coordinating to facilitate proper cell function and development. Materials designed for the precise modulation of subcellular structures captured considerable interest across a spectrum of biomedical uses. These applications span from tumor diagnostics, sensing, and imaging to drug delivery. By facilitating the targeted accumulation of therapeutic agents within organelles, these materials contribute to a noteworthy decrease in necessary therapeutic dosages, thereby minimizing potential side effects. Simultaneously, variations of bioactive species, such as reactive oxygen species, gasotransmitters, etc., within subcellular microenvironments dictate cellular signal conduction, metabolism, and homeostasis. Aberrant expressions of these bioactive molecules can cause disorders associated with various major diseases. Consequently, the essentiality of monitoring bioactive molecules within subcellular structures extends to bioanalysis and the exploration of associated pharmaceutical discoveries. This review offers a comprehensive exploration of published reports to date, delving into the design, molecular imaging, and theranostics associated with materials targeting subcellular structures. Initially, we encapsulate the latest design concepts pertaining to subcellular structure-targeting materials. Subsequently, an overview is provided of the intelligent response mechanisms to the microenvironment within t...