Neighborhood Environment, DNA Methylation, and Presence of Crown-Like Structures of the Breast

作者：Alexandra R. Harris, Jeri D. Hughes, Wayne R. Lawrence, Petra H. Lenz, Jamirra Franklin, Praphulla Bhawsar, Tiffany H. Dorsey, Emily L. Rossi, Catherine M. Pichardo, Margaret S. Pichardo, Alexandra J. White, Cody Ramin, Máire A. Duggan, Mustapha Abubakar, Aaron M. Rozeboom, Jonas S. Almeida, Gretchen L. Gierach, Stefan Ambs, Brittany D. Jenkins · 发表于：JAMA Network Open · 年份：2025 · DOI：10.1001/jamanetworkopen.2024.61334 · 被引用次数：7 · 研究领域：Cancer Risks and Factors、Global Cancer Incidence and Screening、Health, Environment, Cognitive Aging

Importance: Inflammation impacts cancer risk and tumor biological processes, yet studies linking it to social and environmental risk factors are lacking. Objective: To investigate the association of neighborhood deprivation and air pollution with breast adipose inflammation as well as the association between crown-like structures of the breast (CLS-B) and DNA methylation in Black and White women. Design, Setting, and Participants: This cross-sectional study analyzed women with and without breast cancer participating in the National Cancer Institute-Maryland Breast Cancer Study, most of whom were recruited between January 1, 1993, and December 1, 2003, from the University of Maryland Medical Center and surrounding hospitals in the Baltimore, Maryland, area. A small subset of the sample was recruited between March 27, 2012, and November 27, 2017. Noncancerous breast tissue was collected from women who underwent reduction mammoplasty or breast cancer surgery. Statistical analyses were conducted between May and August 2024. Exposures: Two socioenvironmental exposures were examined: air pollution (specifically, fine particulate matter less than 2.5 μm in diameter [PM2.5]) and neighborhood deprivation (measured with Neighborhood Deprivation Index [NDI]). Participant geocodes were linked to 2000 US Census data to calculate PM2.5 concentrations (total mass [μg/m3]) and NDI. Main Outcomes and Measures: Breast tissues underwent immunohistochemical staining for pan-macrophage marker CD6...