Glymphatic dysfunction exacerbates cognitive decline by triggering cortical degeneration in Parkinson's disease: evidence from diffusion-tensor MRI

作者：Yang Zhao, Changyuan Xu, Yufan Chen, Tao Gong, Mengyuan Zhuo, Cheng Zhao, Zhanfang Sun, Weibo Chen, Yuanyuan Xiang, Guangbin Wang · 发表于：Brain Communications · 年份：2024 · DOI：10.1093/braincomms/fcaf029 · 被引用次数：14 · 研究领域：Cerebrospinal fluid and hydrocephalus、Spinal Dysraphism and Malformations、Advanced Neuroimaging Techniques and Applications

Abstract The glymphatic system may play a central role in cognitive impairment associated with Parkinson's disease, but its relationship with regional cortical atrophy is not fully explored. To explore associations among glymphatic dysfunction, regional cortical degeneration and cognitive impairment in Parkinson’s disease participants, we evaluated 51 participants with documented Parkinson’s disease (28 men; age, 61.65 ± 8.27 years) and 30 age- and sex-matched normal controls (11 men; age, 59.2 ± 5.90 years) who underwent 3.0-T MRI of the brain, including high-resolution T1-weighted imaging and diffusion-tensor imaging along the perivascular space as a surrogate for glymphatic flow. Cortical grey matter volume was segmented automatically based on three-dimensional T1-weighted sequences. Cognitive function was assessed by Mini-Mental State Examination. The relationship between glymphatic dysfunction, cognitive decline and regional cortical degeneration was explored. The participants with Parkinson’s disease revealed lower diffusion-tensor imaging along the perivascular space (1.45 ± 0.17 versus 1.64 ± 0.17, P < 0.0001) as compared with normal controls, indicating disturbed glymphatic flow. Glymphatic dysfunction was associated with cognitive scores (r = 0.54, P = 0.003). Diffusion-tensor imaging along the perivascular space values were positively associated with the volume of specific cortical regions (all P-values <0.05) including the temporal pole, posterior or...