Prospective associations between muscle strength and genetic susceptibility to type 2 diabetes with incident type 2 diabetes: a UK Biobank study

作者：Mengyao Wang, Paul J. Collings, Haeyoon Jang, Ziyuan Chen, Qiaoxin Shi, Hin Sheung Ho, Shan Luo, Shiu Lun Au Yeung, Youngwon Kim · 发表于：BMC Medicine · 年份：2025 · DOI：10.1186/s12916-024-03819-9 · 被引用次数：9 · 研究领域：Genetic Associations and Epidemiology、Genetics and Physical Performance、Growth Hormone and Insulin-like Growth Factors

BACKGROUND: This study explored whether the prospective associations between muscle strength and incident type 2 diabetes (T2D) differ by varying levels of genetic susceptibility to T2D. METHODS: This study included 141,848 white British individuals from the UK Biobank. Muscle strength was expressed as the relative value of grip strength (measured by a hand dynamometer) divided by fat-free mass (measured via bioelectrical impedance analysis). Three categories of muscle strength (low, medium and high) were generated based on the sex- and age-specific tertiles. Genetic risk of T2D was estimated using a weighted polygenic risk score based on 138 independent single-nucleotide polymorphisms for T2D. During a median 7.4-year follow-up, 4,743 incident T2D cases were accrued. Cox regression with age as the underlying timescale was fit. RESULTS: High muscle strength was associated with a 44% lower hazard of T2D (HR:0.56, 95%CI:0.52-0.60), compared with low muscle strength, after adjustment for genetic risk of T2D. The inverse association between muscle strength and incident T2D was weaker in individuals with high genetic susceptibility. There was evidence of interaction between muscle strength and genetic susceptibility to T2D (p-additive = 0.010, p-multiplicative = 0.046). The estimated 8-year absolute risk of T2D was lower for high genetic risk-high muscle strength (2.47%), compared with low (2.89%) or medium (4.00%) genetic risk combined with low muscle strength. CONCLUSIONS: Highe...