Phoenix Sepsis Criteria in Critically Ill Children: Retrospective Validation Using a United States Nine-Center Dataset, 2012–2018

作者：Lazaro Nelson Sanchez-Pinto, Latasha A. Daniels, Mihir R. Atreya, Edward Vincent S. Faustino, Reid W. D. Farris, Alon Geva, Robinder G. Khemani, Colin M. Rogerson, Sareen S. Shah, Scott L. Weiss, Tellen D. Bennett · 发表于：Pediatric Critical Care Medicine · 年份：2025 · DOI：10.1097/pcc.0000000000003675 · 被引用次数：35 · 研究领域：Neonatal and Maternal Infections、Sepsis Diagnosis and Treatment、Global Maternal and Child Health

OBJECTIVES: To perform: 1) external validation of the Phoenix Sepsis Score and Phoenix sepsis criteria in a multicenter cohort of critically ill children with infection and a comparison with the 2005 International Pediatric Sepsis Consensus Conference (IPSCC) criteria; 2) a study of Phoenix sepsis criteria performance in patient subgroups based on age and comorbidities; 3) an assessment of microbiological profile of children with Phoenix sepsis; and 4) a study of the performance of the Phoenix-8 score. DESIGN: Secondary, retrospective analysis of a multicenter cohort study from 2012 to 2018. SETTING: Nine PICUs in the United States. PATIENTS: PICU admissions with suspected infection. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among 25,680 encounters of children with suspected or confirmed infection on PICU admission (4.6% in-hospital mortality), 11,168 (43%) met Phoenix criteria for sepsis or septic shock (9% in-hospital mortality). The Phoenix criteria generally outperformed the IPSCC criteria at discriminating mortality in all critically ill children with infections and across all subgroup analyses, including age group, malignancy, or technology dependence. Of 11,168 patients who met Phoenix criteria, 28% were negative for IPSCC criteria for sepsis and these had higher in-hospital mortality than those who met IPSCC sepsis criteria but not Phoenix criteria (4.7% vs.1.7%; p < 0.001), which was similar to the mortality of patients without sepsis (1.3%). Sepsis was ass...