The Phoenix Sepsis Score in Pediatric Oncology Patients With Sepsis at PICU Admission: Test of Performance in a European Multicenter Cohort, 2018–2020

作者：Roelie M. Wösten‐van Asperen, Hannah M la Roi-Teeuw, Wim J. E. Tissing, Iolanda Jordán, Christian Dohna‐Schwake, Gabriella Bottari, John Pappachan, Roman Crazzolara, Angela Amigoni, Agnieszka Mizia‐Malarz, Andrea Moscatelli, María Sánchez‐Martín, Jef Willems, Luregn Jan Schlapbach · 发表于：Pediatric Critical Care Medicine · 年份：2025 · DOI：10.1097/pcc.0000000000003683 · 被引用次数：17 · 研究领域：Sepsis Diagnosis and Treatment、Neonatal and Maternal Infections、Antibiotic Resistance in Bacteria

OBJECTIVES: The Pediatric Sepsis Definition Task Force developed and validated a new organ dysfunction score, the Phoenix Sepsis Score (PSS), as a predictor of mortality in children with suspected or confirmed infection. The PSS showed improved performance compared with prior scores. However, the criteria were derived in a general pediatric population, in which only 10% had cancer. Given that pediatric cancer patients with sepsis have higher mortality compared with noncancer patients with sepsis, we aimed to assess the PSS in PICU patients with cancer and sepsis. DESIGN: Retrospective multicenter cohort study. SETTING: Twelve PICUs across Europe. PATIENTS: Each PICU identified patients 18 years young or younger, with underlying malignancy and suspected or proven sepsis, and admission between January 1, 2018, and January 1, 2020. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The PSS and three other scores, including Phoenix-8, Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score, and pediatric Sequential Organ Failure Assessment (pSOFA) score, were calculated for comparison. The primary outcome was 90-day all-cause mortality. We compared score performance using area under the receiver operating characteristic curve (AUROC) and area under the precision-recall curve (AUPRC) analyses. Among 383 patients with proven or suspected sepsis, 90-day mortality was 19.3% (74/383). We failed to identify an association between a particular score and performance for 90-day mortality....