Association between air pollution and cardiovascular disease risk in middle-aged and elderly individuals with diabetes: inflammatory lipid ratio accelerate this progression

作者：Chunyu Yan, Guang Chen, Yingyu Jing, Qi Ruan, Ping Liu · 发表于：Diabetology & Metabolic Syndrome · 年份：2025 · DOI：10.1186/s13098-025-01638-3 · 被引用次数：7 · 研究领域：Air Quality and Health Impacts、Biomarkers in Disease Mechanisms、Heme Oxygenase-1 and Carbon Monoxide

Long-term exposure to air pollution significantly increases the risk of cardiovascular disease (CVD); however, the association and underlying mechanisms in individuals with diabetes remain unconfirmed. We used data from the China Health and Retirement Longitudinal Study (CHARLS) to follow 5,430 adults over a four-year period. Baseline CVD and diabetes status were determined, and high-resolution data were used to assess air pollution exposure to PM 1 , PM 2.5 , PM 10 , and O 3 . The inflammatory lipid ratio (ILR) was calculated to reflect inflammatory and lipid metabolic states. A generalized linear model (GLM) was employed to analyze the effects of air pollution and ILR on diabetes-related CVD risk. The prevalence of CVD was 8.5% in the healthy population and 13.8% in the diabetic population. Air pollution exposure was significantly associated with an increased risk of CVD among diabetic individuals. For each interquartile range (IQR) increase in concentrations of pollutants O 3 , PM 1 , PM 10 , and PM 2.5 , CVD risk in the diabetic group rose by 21%, 19%, 28%, and 19%, respectively. Higher ILR values were positively associated with CVD incidence (OR = 1.019, 95% CI: 1.001–1.037, P < 0.05), with a nonlinear relationship observed between ILR levels and CVD risk ( P Nonlinear = 0.0381), indicating that higher ILR values exacerbate the impact of air pollution on diabetic individuals. Among middle-aged and older adults with diabetes, exposure to air pollution is associated with a...