Abnormal static and dynamic functional connectivity of striatal subregions in patients with obsessive-compulsive disorder

作者：Wen‐Qing Shi, Ya Tian, Huiting Yang, Huirong Guo, Baohong Wen, Zijun Liu, Yong Zhang, Shaoqiang Han, Jingliang Cheng · 发表于：Frontiers in Psychiatry · 年份：2025 · DOI：10.3389/fpsyt.2025.1529983 · 被引用次数：5 · 研究领域：Obsessive-Compulsive Spectrum Disorders、Transcranial Magnetic Stimulation Studies、Functional Brain Connectivity Studies

Background: As a crucial node of the cortico-striato-thalamo-cortical (CSTC) loop, the striatum has long been considered to be involved in the pathophysiology of obsessive-compulsive disorder (OCD). Numerous neuroimaging studies have reported functional abnormalities of the striatum in OCD. However, altered dynamic functional connectivity (DFC) patterns of striatal subregions were rarely reported in patients with OCD. Methods: We collected resting-state functional MRI data from 97 first episode and drug-naïve OCD patients and 106 HCs matched for gender and age. Seed-based whole-brain resting-state functional connectivity (RSFC) and DFC analysis were performed for 12 striatal subregions. Between-group differences of the mean RSFC and DFC were determined using a two-sample t-test. In addition, we performed a Spearman's correlation analysis to examine the relationship between altered RSFC and DFC and the clinical characteristics of OCD. Results: Patients with OCD exhibited increased RSFC between the superior ventral striatum (VSs) and the calcarine (CAL), lingual gyrus (LING), cuneus (CUN), supplementary motor area (SMA), precuneus (PCUN), paracentral lobule (PCL) and superior parietal gyrus (SPG). Increased RSFC between the left dorsal caudal putamen (DCP) and LING and inferior occipital gyrus (IOG) and increased RSFC between left ventral rostral putamen (VRP) and fusiform gyrus (FFG) were also found. in OCD group. The left dorsal caudate (DC) showed increased RSFC with CAL. In...