Correlation of neutrophil percentage-to-albumin ratio with lung function in American adults: a population study

作者：Xiaolin Zhang, Fan Bai, Haibin Ni, Shiyuan Chen, Dan Fu, Haiyan Ren, Bin Hu · 发表于：BMC Pulmonary Medicine · 年份：2025 · DOI：10.1186/s12890-025-03537-9 · 被引用次数：5 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Chronic Obstructive Pulmonary Disease (COPD) Research、Respiratory Support and Mechanisms

BACKGROUND: Chronic respiratory diseases pose a significant threat to global health, underscoring the urgent need for effective preventative and therapeutic interventions. The neutrophil-to-albumin ratio (NPAR), an emerging biomarker for inflammation and nutritional status, has shown promising associations with respiratory health, necessitating an investigation into its potential for predicting lung function decline. OBJECTIVE: This study aimed to delineate the relationship between the NPAR and pulmonary function within a sample of the American adult population and assess the viability of the NPAR as a prognostic indicator for compromised lung function. METHODS: With data available from the National Health and Nutrition Examination Survey (NHANES) for the years 2007 to 2012, 10,055 American adults who met the exclusion criteria were included in the current study. Multivariate linear regression, smoothed curve fitting, and subgroup analyses were applied to evaluate the associations observed between the NPAR and lung function indicators. RESULTS: Even after accounting for all potential confounding factors, a significant inverse relationship persisted between the NPAR and key lung function indicators, including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and peak expiratory flow rate (PEF). This association remained robust even after potential confounding factors were considered. Subgroup analysis revealed that the negative correlation was more pr...