A short-term, high-caloric diet has prolonged effects on brain insulin action in men

作者：Stephanie Kullmann, Lore Wagner, Robert Hauffe, Anne Kühnel, Leontine Sandforth, Ralf Veit, Corinna Dannecker, Jürgen Machann, Andreas Fritsche, Norbert Stefan, Hubert T. Preissl, Nils B. Kroemer, Martin Heni, André Kleinridders, Andreas L. Birkenfeld · 发表于：Nature Metabolism · 年份：2025 · DOI：10.1038/s42255-025-01226-9 · 被引用次数：26 · 研究领域：Regulation of Appetite and Obesity、Diet and metabolism studies、Biochemical Analysis and Sensing Techniques

Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in healthy weight men. Hence, brain response to insulin can adapt to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases.