Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of stratified aggregate data

作者：David A. Jolliffe, Carlos A. Camargo, John Sluyter, Mary Aglipay, John F. Aloia, Peter Bergman, Heike Annette Bischoff-Ferrari, Arturo Borzutzky, Vadim Y. Bubes, Camilla Trab Damsgaard, Francine Monique Ducharme, Gal Dubnov‐Raz, Susanna Esposito, Davaasambuu Ganmaa, Clare Gilham, Adit A. Ginde, Inbal Golan‐Tripto, Emma C Goodall, Cameron Charles Grant, Chris Griffiths, Anna Maria Hibbs, Wim Janssens, Anuradha Vaman Khadilkar, Ilkka Laaksi, Margaret T. Lee, Mark B Loeb, Jonathon L. Maguire, Paweł Majak, Semira Manaseki‐Holland, JoAnn E. Manson, David T. Mauger, David R. Murdoch, Akio Nakashima, Rachel Ε. Neale, Hai D. Pham, Christine Rake, Judy R. Rees, Jenni Rosendahl, Robert K.R. Scragg, Dheeraj Shah, Yoshiki Shimizu, Steve Simpson, Geeta Trilok Kumar, Mitsuyoshi Urashima, Adrian R. Martineau · 发表于：The Lancet Diabetes & Endocrinology · 年份：2025 · DOI：10.1016/s2213-8587(24)00348-6 · 被引用次数：37 · 研究领域：Vitamin D Research Studies、Vitamin C and Antioxidants Research、Chronic Obstructive Pulmonary Disease (COPD) Research

Background A 2021 meta-analysis of 37 randomised controlled trials (RCTs) of vitamin D supplementation for prevention of acute respiratory infections (ARIs) revealed a statistically significant protective effect of the intervention (odds ratio [OR] 0·92 [95% CI 0·86 to 0·99]). Since then, six eligible RCTs have been completed, including one large trial (n=15 804). We aimed to re-examine the link between vitamin D supplementation and prevention of ARIs. Methods Updated systematic review and meta-analysis of data from RCTs of vitamin D for ARI prevention using a random effects model. Subgroup analyses were done to determine whether effects of vitamin D on risk of ARI varied according to baseline 25-hydroxyvitamin D (25[OH]D) concentration, dosing regimen, or age. We searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, and the ClinicalTrials.gov between May 1, 2020 (end-date of search of our previous meta-analysis) and April 30, 2024. No language restrictions were imposed. Double-blind RCTs supplementing vitamin D for any duration, with placebo or lower-dose vitamin D control, were eligible if approved by a Research Ethics Committee and if ARI incidence was collected prospectively and pre-specified as an efficacy outcome. Aggregate data, stratified by baseline 25(OH)D concentration and age, were obtained from study authors. The study was registered with PROSPERO (no. CRD42024527191). Findings We identified six new RCTs (19 337 participant...