The Effect of Ketamine-Assisted Group Therapy on Treatment-Resistant Mental Health Conditions in Firefighters

作者：Vivian W. L. Tsang, Michelle CQ Lin, Cassandra M. Choles, Pamela Kryskow · 发表于：Journal of Occupational and Environmental Medicine · 年份：2025 · DOI：10.1097/jom.0000000000003352 · 被引用次数：4 · 研究领域：Psychedelics and Drug Studies、Posttraumatic Stress Disorder Research、Nicotinic Acetylcholine Receptors Study

OBJECTIVE: Firefighters display elevated risk for diagnoses of mental health illnesses. Psychedelic-assisted therapies show promise in the treatment of clinically challenging conditions. This observational case series analyzed data from firefighters with mental health diagnoses who participated in a 12-week ketamine-assisted group therapy treatment plan. METHODS: Questionnaire scores (Generalized Anxiety Disorder Assessment-7, Patient Health Questionnaire-9, The Posttraumatic Stress Disorder Checklist -5, Brief Inventory of Psychosocial Functioning ) collected throughout the program were scored and statistically analyzed for changes. Qualitative data were analyzed through thematic analysis. RESULTS: Significant decreases with large effect sizes were detected in Generalized Anxiety Disorder Assessment-7 and The Posttraumatic Stress Disorder Checklist-5 scores after completion in the 12-week treatment plan, which persisted 6 months later. Participants noted it was beneficial being in a cohort with fellow firefighters. CONCLUSIONS: Statistically and clinically significant improvements to posttraumatic stress disorder and anxiety diagnoses were detected in the cohort of firefighters after the Roots to Thrive Ketamine-Assisted Group Therapy program, with results retained six months post treatment.