Epigenetic Mechanisms in the Pathophysiology and Progression of Epilepsy: A Comprehensive Review of Experimental and Clinical Studies

作者：Yinchao Li, Zhengwei Su, Ke Zhao, Xianyue Liu, Shuda Chen, Xiaofeng Yang, Liemin Zhou · 发表于：Current Neuropharmacology · 年份：2025 · DOI：10.2174/1570159x23666241220163832 · 被引用次数：11 · 研究领域：Epigenetics and DNA Methylation、Genetics and Neurodevelopmental Disorders、MicroRNA in disease regulation

Epilepsy is a prevalent neurological disorder that presents with a diverse range of clinical manifestations and etiologies influenced by both genetic and environmental factors. However, traditional genetic mechanisms alone are insufficient to fully elucidate the pathogenesis of epilepsy, highlighting the increasing importance of epigenetics in epilepsy research. Several studies have demonstrated that epigenetic mechanism play a pivotal role in the development and progression of epilepsy. This review provides a comprehensive overview of epigenetic regulation and its role in epilepsy. We emphasize the specific role of epigenetic regulation, including DNA methylation, non-coding RNA, and histone modification in the epilepsy. Finally, we discuss the potential applications of epigenetic regulation in the etiology research, drug development, and personalized therapy of epilepsy, along with the technical and theoretical challenges that need to be addressed in epigenetic research. Epigenetic mechanisms have emerged as a promising avenue for understanding the pathogenesis and treatment of epilepsy. However, to thoroughly grasp its potential implications for the clinical management of this disease, a deeper understanding of the role of epigenetics in TLE is essential. Therefore, further research is required to elucidate the specific epigenetic mechanisms involved in epilepsy, their interactions with other disease-related factors, and their potential as therapeutic targets. Such researc...