Efficacy of probiotics combined with metformin and a calorie-restricted diet in obese patients with polycystic ovary syndrome

作者：Jin Luo, Zhenyu Li, Zhibin Wang, Yashuang Ding, Peng Gao, Yuping Li · 发表于：Pakistan Journal of Medical Sciences · 年份：2025 · DOI：10.12669/pjms.41.3.10554 · 被引用次数：4 · 研究领域：Ovarian function and disorders、Lipid metabolism and disorders、Gastrointestinal motility and disorders

Objective: To explore the efficacy of probiotics combined with metformin and a calorie-restricted diet in obese patients with polycystic ovary syndrome (PCOS). Methods: Clinical data of 141 obese PCOS patients treated in the 73rd Group Army Hospital from June 2021 to December 2023 were retrospectively analyzed. Patients were grouped according to the treatment records: metformin group (n=69), patients treated with metformin and a calorie-restricted diet) and combined group (n=72, patients treated with probiotics combined with metformin and a calorie-restricted diet). Levels of endocrine hormone indicators, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), Fasting blood glucose (FPG), gut microbiota status, and Body mass index (BMI) were compared before and after the treatment in two groups. Results: After the treatment, the levels of endocrine hormone indicators, HOMA-IR, and FPG in both groups were significantly reduced compared to pre-treatment levels and were significantly lower in the combined group compared to the metformin group (P<0.05). Abundance of gut microbiota and Shannon Wiener diversity index in both groups significantly increased after the treatment and were markedly higher in the combined group than in the metformin group (P<0.05). Treatment led to a significant reduction in the body mass index (BMI) in all patients (P<0.05). However, post-treatment BMI was comparable in the two groups (P>0.05). Conclusions: In obese patients with PCOS, ...