Prevalence, clinical management, and outcomes of adults hospitalised with endemic arbovirus illness in southeast Europe (MERMAIDS-ARBO): a prospective observational study

作者：Louise Sigfrid, Louise Sigfrid, Xin Hui S Chan, Louella M.R. Kasbergen, Lauren Hookham, Jia Wei, Siyu Chen, James Lee, Reina S Sikkema, Erwin de Bruin, Victor M. Corman, Chantal Reusken, Katherine Loens, Corneliu Petru Popescu, Mihaela Lupșe, Violeta Briciu, Pëllumb Pipero, Arjan Harxhi, Edmond Puca, Albina Ponosheci Biçaku, Maja Travar, Maja Ostojić, Rusmir Baljić, Jurica Arapović, Dragan Ledina, Đurđica Cekinović Grbeša, Ivica Čabraja, Anca Meda Văsieşiu, Ivan-Christian Kurolt, Stela Halichidis, Victoria Bîrluțiu, Željana Sulaver, Irina Magdalena Dumitru, Ruxandra Moroti, Aleksandra Barać, Goran Stevanović, Athina Pyrpasopoulou, Metaxia Papanikolaou, Vasilios Koulouras, Ljiljana Radić, Emmanuel Roilides, Alemka Markotić, Ushma Galal, Emmanuelle Denis, Lynsey Goodwin, Lance Turtle, Iosif Marincu, Simin Aysel Florescu, Hamdi Ramadani, Rémi N. Charrel, Herman Goossens, Margareta Ieven, Christian Drosten, Peter Horby, Marion P G Koopmans, Louella M R Kasbergen, Erwin De Bruin, Felicity Chandler, Louise Sigfrid, Louise Sigfrid, Xin-Hui S Chan, Lauren Hookham, Jia Wei, Siyu Chen, Corine H GeurtsvanKessel, Sandra Scherbeijn, Remi N Charrel, Nazlı Ayhan, James L Lee, Victor M Corman, Chantal Reusken, Katherine Loens, Corneliu Petru Popescu, Mihaela Lupse, Violeta Briciu, Anca Meda Vasiesiu, Pellumb Pipero, Arjan Harxhi, Edmond Puca, Albina Ponosheci Biçaku, Maja Travar, Maja Ostojić, Rusmir Baljic, Jurica Arapović, Dragan Ledina, Đurđica Cekinović Grbeša, Ivica Čabraja, Ivan-Christian Kurolt, Stela Halichidis, Victoria Birlutiu, Irina M Dumitru, Ruxandra Moroti, Aleksandra Barac, Goran Stevanovic, Athina Pyrpasopoulou, Vasilios Koulouras, Ljiljana Betica Radić, Metaxia N Papanikolaou, Ioannis Andrianopoulos, Catalin Apostolescu, Silvia Bino, Maria Chondrogiorgi, Natalie Cleton, Daniel Codreanu, Tomasović Domagoj, Edita Dražić Maras, Mario Duvnjak, Adriana Hristea, Raluca M Hrisca, Kevin Jacobs, Ilias Iosifidis, Puškarić Ivana, Alma Gabriela Kosa, Iris Koshovari, Mandy Kuijstermans, Arsim Kurti, Santini Marija, Iosif Marincu, Julia Melchert, Pieter Moons, Visnja Mrdjen, Cristian M Niculae, Nenad Pandak, Lul Raka, Iordanis Romiopoulos, Željana Sulaver, Gratiela Tardei, Nijaz Tihic, Skuhala Tomislava, Antonija Verhaz, Mihaela Zaharia, Mačak Šafranko Željka, Ivana Vrkic, Ankica Vujovic, Emmanuel Roilides, Alemka Markotić, Ushma Galal, Emmanuelle Denis, Lynsey Goodwin, Lance Turtle, Simin Aysel Florescu, Hamdi Ramadani, Herman Goossens, Margareta Ieven, Christian Drosten, Peter W Horby, Reina S. Sikkema, Marion Koopmans · 发表于：The Lancet Infectious Diseases · 年份：2025 · DOI：10.1016/s1473-3099(24)00655-8 · 被引用次数：8 · 研究领域：Viral Infections and Vectors、Mosquito-borne diseases and control、Viral Infections and Outbreaks Research

BACKGROUND: Arboviruses have expanded into new regions in Europe, yet data indicate gaps in disease notifications and a risk of further spread. We aimed to report on prevalence, clinical management, and outcomes of endemic arbovirus infections in southeast Europe. METHODS: In this prospective observational study (MERMAIDS-ARBO), we enrolled adults (age ≥18 years) hospitalised with an arbovirus-compatible disease syndrome within 21 days of symptom onset across 21 hospitals in seven countries in southeast Europe over four arbovirus seasons (May 1-Oct 31, during 2016-19). We obtained data from case report forms completed by site investigators on admission and discharge. Participants were excluded if they had non-infectious CNS disorders, symptoms of another confirmed cause, an identified focal source of infection, or symptoms caused by recurrence of a pre-existing condition. The primary outcome was the proportion of participants with confirmed or probable acute infections with West Nile virus (WNV), tick-borne encephalitis virus (TBEV), Crimean-Congo haemorrhagic fever virus (CCHFV), or Toscana virus (TOSV), per reference laboratory criteria. Secondary outcomes were the proportions of patients treated with antivirals, antibiotics, or corticosteroids; the proportion of patients requiring intensive care; hospital length of stay; and mortality. FINDINGS: Of 2896 adults screened for eligibility, 929 were recruited and 913 met protocol-defined eligibility criteria (median age 43·1 ye...