Atroposelective synthesis of N–N axially chiral pyrrolylamides by combined-acid catalytic Paal–Knorr reaction

作者：Zhihuang Chen, Qi Chen, Guo-Gang Tu, Xiaodong Xiong · 发表于：Chemical Communications · 年份：2025 · DOI：10.1039/d4cc06721e · 被引用次数：7 · 研究领域：Axial and Atropisomeric Chirality Synthesis、Molecular spectroscopy and chirality

A general and efficient method for the construction of enantiomerically pure N-N axially chiral pyrrolylamides by utilizing the catalytic asymmetric Paal-Knorr reaction has been developed. The key to success is the use of the binary-acid catalytic system involving the dramatic synergistic effect of a Lewis acid and a chiral phosphoric acid for achieving effective stereocontrol.