Synthesis of pyrrole derivatives via ordered isocyanide insertion reaction driven by ring strain mediated by non-covalent bond interactions

作者：Shanshan Liu, Jiangnan Zheng, Zhiwen Zhao, Yi Zhang, Ping He, Yong‐Jie Wu, Jiangtao Feng, Long Wang, Zhi‐Lin Ren · 发表于：Organic Chemistry Frontiers · 年份：2025 · DOI：10.1039/d4qo02144d · 被引用次数：10 · 研究领域：Synthesis and Characterization of Pyrroles、Synthesis and Reactivity of Heterocycles、Synthesis and pharmacology of benzodiazepine derivatives

An efficient synthesis of pyrrole derivatives is achieved via ordered isocyanide insertion, driven by ring strain and mediated by non-covalent bonds. Notably, α,β-unsaturated ketone acts as both a directing group and substrate.