LCN2 deficiency mitigates the neuroinflammatory damage following acute glaucoma

作者：Tu Hu, Shuhan Meng, Can Liu, Weizhou Fang, Zhao-hua Xia, Yiqun Hu, Jia Luo, Xiaobo Xia · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.104752 · 被引用次数：20 · 研究领域：Neurological Disorders and Treatments、Glaucoma and retinal disorders、Flavonoids in Medical Research

A "neuroinflammatory cascade" characterized by breakdown of inner BRB, peripheral immune cell infiltration, and innate immune cell response occurs during the initial stage following glaucomatous injury. We also identified a novel mechanism for LCN2 in acute high IOP-induced neuroinflammation. LCN2 has the potential to serve as a candidate biomarker for predicting the severity of the neuroinflammatory response following acute glaucoma, which may provide new evidence to retinal repair strategies for better visual function recovery at intervention time points and new targets.