TFEB promotes Ginkgetin-induced ferroptosis via TRIM25 mediated GPX4 lysosomal degradation in EGFR wide-type lung adenocarcinoma

作者：Haojie Wang, Ling-feng Dong, Lili Ding, Xiu-Yuan Miao, Yuwen Zhang, Liping Zhao, Lihua Yu, Zhen-Rong Guan, Ya-Ping Jiang, Xiaoqi Tang, Ya-Xin Yan, Jian-Shu Lou · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.106469 · 被引用次数：17 · 研究领域：Ferroptosis and cancer prognosis、RNA modifications and cancer、Cancer-related molecular mechanisms research

: This study identifies, for the first time, GK as a promising TFEB agonist for LUAD treatment. TFEB activation promotes TRIM25-mediated K48-linked polyubiquitination and lysosomal degradation of GPX4, driving ferroptosis. This ferroptosis-driven mechanism offers a novel strategy to enhance ferroptosis-based anti-LUAD therapies.