PBRM1 deficiency enhances PD1 immunotherapeutic sensitivity via chromosomal accessibility in colorectal cancer

作者：Rui Li, Jie He, Chaoqun Liu, Zesheng Jiang, Jiasheng Qin, Kun Liang, Zhongzhong Ji, Liang Zhao · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.100793 · 被引用次数：10 · 研究领域：Immune Cell Function and Interaction、Cancer Immunotherapy and Biomarkers、Extracellular vesicles in disease

Our study established that PBRM1/Pbrm1 deficiency was positively correlated with PD1 immunotherapeutic sensitivity in colorectal cancer. The underlying molecular mechanisms involved regulation of chromosome accessibility, activation of the NF-κB signaling pathway, and immune cell infiltration in the microenvironment. These findings identify potential molecular targets for enhancing immunotherapy for colorectal cancer.