Post-Hospitalisation COVID-19 Rehabilitation (PHOSP-R): a randomised controlled trial of exercise-based rehabilitation

作者：Enya Daynes, Rachael A Evans, Neil J. Greening, NICOLETTE CLAIRE BISHOP, Thomas E. Yates, Daniel Lozano-Rojas, Kimon Ntotsis, Matthew Richardson, Molly M Baldwin, Malik Hamrouni, Emily Hume, Hamish J. C. McAuley, George Mills, Dimitrios Megaritis, Matthew J Roberts, Charlotte E. Bolton, James Duncan Chalmers, Trudie Chalder, Annemarie Beth Docherty, Omer Elneima, Ewen M Harrison, Victoria Claire Harris, Ling‐Pei Ho, Alex Robert Horsley, Linzy Houchen‐Wolloff, Olivia C. Leavy, Michael Marks, Krishna Poinasamy, Jennifer Kathleen Quint, Betty Raman, Ruth M. Saunders, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Sarah Terry, Louise V. Wain, William D‐C Man, Carlos Echevarria, Ioannis Vogiatzis, Christopher Edward Brightling, Sally J. Singh · 发表于：European Respiratory Journal · 年份：2025 · DOI：10.1183/13993003.02152-2024 · 被引用次数：36 · 研究领域：Long-Term Effects of COVID-19、COVID-19 and Mental Health、Exercise and Physiological Responses

Objective Post-COVID syndrome involves prolonged symptoms with multisystem and functional impairment lasting ≥12 weeks after acute coronavirus disease 2019 (COVID-19). We aimed to determine the efficacy of exercise-based rehabilitation interventions, either face-to-face or remote, compared to usual care in individuals experiencing post-COVID syndrome following a hospitalisation with acute COVID-19. Design This single-blind randomised controlled trial compared two exercise-based rehabilitation interventions (face-to-face or remote) to usual care in participants with post-COVID syndrome following a hospitalisation. The interventions were either a face-to-face or remote 8-week programme of individually prescribed exercise and education. The primary outcome was the change in Incremental Shuttle Walking Test (ISWT) following 8 weeks of intervention (either face-to-face or remote) compared to usual care. Other secondary outcomes were measured including health-related quality of life (HRQoL), and exploratory outcomes included lymphocyte immunotyping. Results 181 participants (55% male, mean±sdage 59±12 years, length of hospital stay 12±19 days) were randomised. There was an improvement in the ISWT distance following face-to-face rehabilitation (mean 52 m, 95% CI 19–85 m; p=0.002) and remote rehabilitation (mean 34 m, 95% CI 1–66 m; p=0.047) compared to usual care alone. There were no differences between groups for HRQoL self-reported symptoms. Analysis of immune markers revealed sig...