Continuous replenishment of the dysfunctional CD8 T cell axis is associated with response to chemoimmunotherapy in advanced breast cancer

作者：Christina Metoikidou, Vadim K Karnaukhov, Bram Boeckx, Eleonora Timperi, Pierre‐Emmanuel Bonté, Ling Wang, Marion Espenel, Benoît Albaud, Delphine Loirat, Xiaoxiao Wang, Christos P. Sotiriou, Philippe Georges Aftimos, Kevin Punie, Hans P. M. W. Wildiers, Viktorija Labroska, Mingwei Wang, Joshua J. Waterfall, Martine J Piccart, Thierry Mora, Aleksandra M. Walczak, Olivier J Lantz, Laurence Buisseret, Diether Lambrechts, Sebastián Amigorena, Emanuela Romano · 发表于：Cell Reports Medicine · 年份：2025 · DOI：10.1016/j.xcrm.2025.101973 · 被引用次数：5 · 研究领域：Immune Cell Function and Interaction、CAR-T cell therapy research、Cancer Immunotherapy and Biomarkers

precursors. Collectively, our data suggest that baseline clonal expansion could be a potential predictor of response and that both clonal reinvigoration of pre-existing tumor-reactive T cells and clonal replacement on-treatment are important for a protective response to chemoimmunotherapy.