Effect of remimazolam combined with estazolam on anxiety levels and postoperative gastrointestinal function recovery in patients undergoing laparoscopic cholecystectomy surgery

作者：Shimeng Mao, Ruijia Gao, Yu Huang, Hongyan He, Jinliang Yao, Jiying Feng · 发表于：European journal of medical research · 年份：2025 · DOI：10.1186/s40001-025-02381-1 · 被引用次数：5 · 研究领域：Enhanced Recovery After Surgery、Music Therapy and Health、Intensive Care Unit Cognitive Disorders

PURPOSE: The objective of this study is to examine the impact of administering remimazolam and estazolam in alleviating preoperative anxiety on the recovery of gastrointestinal function in patients undergoing laparoscopic cholecystectomy surgery. MATERIALS AND METHODS: A total of 140 patients who were scheduled for elective laparoscopic cholecystectomy surgery were randomly divided into four groups using random number table: remimazolam group (group R, n = 35), estazolam group (group E, n = 35), remimazolam combined with estazolam group (group RE, n = 35), and control group (group C, n = 35). Group R received an intravenous injection of remimazolam before the administration of anesthesia, group E was orally administered estazolam on the night before surgery and intravenously injected with normal saline before induction of anesthesia, group RE received both estazolam orally on the night before surgery and intravenous injection of remimazolam before induction of anesthesia, and group C was given normal saline before induction of anesthesia. The visual analogue scale for anxiety (VAS-A) scores were documented during the preoperative visit, following entry into the operating room, and 10 min after intravenous remimazolam or normal saline. Time to the first postoperative exhaust and defecation, occurrence of nausea and vomiting within 24 h after surgery, sleep quality scores on the night before surgery and two nights after surgery as per Numerical Rating Scale (NRS), postoperative...