Preoperative inflammatory markers and tumor markers in predicting lymphatic metastasis and postoperative complications in colorectal cancer: a retrospective study

作者：Huiming Wu, Yize Wang, Min Deng, Zhensheng Zhai, Dingwen Xue, Fei Luo, Huiyu Li · 发表于：BMC Surgery · 年份：2025 · DOI：10.1186/s12893-025-02795-y · 被引用次数：15 · 研究领域：Colorectal Cancer Surgical Treatments、Inflammatory Biomarkers in Disease Prognosis、Lymphatic System and Diseases

OBJECTIVE: To analyze the impact of preoperative inflammatory markers and tumor markers on lymphatic metastasis and postoperative complications in colorectal cancer patients, and explore their predictive value for these outcomes. Furthermore, based on the preoperative inflammatory and tumor marker indicators with significant effects, predictive models for the risk of lymphatic metastasis and the incidence of postoperative complications will be constructed. METHODS: This study retrospectively analyzed the clinical data of CRC patients who underwent surgical treatment at Shanxi Bethune Hospital between January 2021 and June 2024. Preoperative inflammatory markers and tumor markers were compared between the lymph node-positive and lymph node-negative groups. Variables were selected using Lasso regression, and independent factors influencing lymph node metastasis were identified through multivariate logistic regression analysis. Based on these results, a Nomogram prediction model was constructed, and its accuracy was evaluated using a calibration curve. The discriminatory ability of the model was assessed with the ROC curve, and its clinical applicability was analyzed using the DCA curve. Similarly, for predicting postoperative complications, Pearson correlation analysis was used to examine the relationships between preoperative inflammatory markers, tumor markers, and complications. ROC curves were employed to calculate the AUC and optimal cutoff values for each marker. Kaplan-M...