Biocatalytic atroposelective synthesis of heterobiaryls and heterobiaryl N -oxides via dynamic kinetic resolution

作者：Xinyue Hao, Bin Wang, Zhuangfei Tian, Zhouchang Yao, Tianzhang Qiao, Ling Huang, Haigen Fu · 发表于：Organic Chemistry Frontiers · 年份：2025 · DOI：10.1039/d5qo00011d · 被引用次数：17 · 研究领域：Axial and Atropisomeric Chirality Synthesis、Chemical synthesis and alkaloids、Molecular spectroscopy and chirality

A highly efficient biocatalytic dynamic kinetic resolution (DKR) for the asymmetric synthesis of axially chiral heterobiaryls and heterobiaryl N -oxides was developed using engineered imine-reductases (IREDs).