Insomnia and Female Reproductive Diseases: A Cross-Sectional and Mendelian Randomization Study

作者：Liyuan Fang, Yan Wang, Runxi Wang, Yuhang Fang, Yi Xie, Shuhan Yang, Suying Liu, Ying Zhang · 发表于：International Journal of Women s Health · 年份：2025 · DOI：10.2147/ijwh.s498231 · 被引用次数：3 · 研究领域：Sleep and related disorders、Circadian rhythm and melatonin、Ovarian function and disorders

Background: Insomnia is increasingly emerging as a significant concern in public health, with a longstanding emphasis on its relationship with overall well-being. Nevertheless, few research has been devoted to investigating the relationship between insomnia and female reproductive health. Methods: In our study, we conducted a Mendelian randomization (MR) study to estimate the causal relationship between insomnia and female reproductive diseases. A total of 268 independent genetic variants associated with insomnia at the genome-wide significance level (P < 5× 10 − 8 ) were used as instrumental variables. Summary-level data were obtained from the UK Biobank and Finn Gen study, including ovarian cysts, polycystic ovarian syndrome (PCOS), endometriosis, premature ovarian insufficiency (POI), ovarian cancer (OC), uterine fibroids, endometrial cancer (EC) and female infertility. We performed logistic regression to assess the associations between insomnia and the risk of OC and EC by using data from the National Health and Nutrition Examination Survey (NHANES) 2013– 2014. Results: Our research reveals that genetic liability to insomnia constitutes a risk factor for ovarian cysts (odds ratio [ OR ]: 1.44, 95% confidence interval [ CI ]: 1.21– 1.72, P < 0.05), PCOS ( OR : 1.67, 95% CI : 1.44– 1.94, P < 0.05), and endometriosis ( OR : 1.43, 95% CI : 1.16– 1.76, P < 0.05). However, we found no statistically significant associations between insomnia and POI, OC, uterine fibroids, EC, or ...