Radiomics Integration of Mammography and DCE-MRI for Predicting Molecular Subtypes in Breast Cancer Patients

作者：Xianwei Yang, Jing Li, Hang Sun, Jing Chen, Jin Xie, Yonghui Peng, Tao Shang, Tongyong Pan · 发表于：Breast Cancer Targets and Therapy · 年份：2025 · DOI：10.2147/bctt.s488200 · 被引用次数：4 · 研究领域：Radiomics and Machine Learning in Medical Imaging、MRI in cancer diagnosis、Breast Cancer Treatment Studies

Background: Accurate identification of the molecular subtypes of breast cancer is essential for effective treatment selection and prognosis prediction. Aim: This study aimed to evaluate the diagnostic performance of a radiomics model, which integrates breast mammography and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in predicting the molecular subtypes of breast cancer. Methods: We retrospectively included 462 female patients with pathologically confirmed breast cancer, including 53 cases of triple-negative, 94 cases of HER2 overexpression, 95 cases of luminal A, and 215 cases of luminal B breast cancer. Radiomics analysis was performed using FAE software, wherein the radiomic features were examined about the hormone receptor status. The performance of the model was evaluated using the area under the receiver operating characteristic curve (AUC) and accuracy. Results: In multivariate analysis, radiomic features were the only independent predictive factors for molecular subtypes. The model that incorporates multimodal fusion features from breast mammography and DCE-MRI images exhibited superior overall performance compared to using either modality independently. The AUC values (or accuracies) for six pairings were as follows: 0.648 (0.627) for luminal A vs luminal B, 0.819 (0.793) for luminal A vs HER2 overexpression, 0.725 (0.696) for luminal A vs triple-negative subtype, 0.644 (0.560) for luminal B vs HER2 overexpression, 0.625 (0.636) for luminal B vs tr...