Preferences for HIV pre‐exposure prophylaxis formulations and delivery among young African women: results of a discrete choice experiment

作者：Wendy W. Dlamini, Brenda Gati Mirembe, Meighan Krows, Sue Peacock, Philip Kotze, Pearl Selepe, Jenni Smit, Nelly Mandona, Cheryl Louw, Harriet Nuwagaba‐Biribonwoha, Victor Omollo, Zinhle Zwane, Ravindre Panchia, Noluthando Mwelase, Melissa Senne, Logashvari Naidoo, Rachel Chihana, Sinéad Delany‐Moretlwe, Katherine Gill, Pippa Macdonald, Alastair van Heerden, Shannon Bosman, Remco P. H. Peters, Philip du Preez, Amy Ward, Connie Celum, Renee Heffron, Jennifer Velloza, for the INSIGHT Study Team · 发表于：Journal of the International AIDS Society · 年份：2025 · DOI：10.1002/jia2.26422 · 被引用次数：4 · 研究领域：HIV/AIDS Research and Interventions、Economic and Environmental Valuation、HIV Research and Treatment

INTRODUCTION: Oral HIV pre-exposure prophylaxis (PrEP) is highly effective, but adherence is challenging for young women. Products centred around women's preferences could address adherence barriers. Using a longitudinal discrete choice experiment (DCE), we examined young African women's preferences around PrEP product formulation and delivery attributes before and after initiating oral PrEP. METHODS: We enrolled HIV-negative women from six African countries in a prospective cohort from August 2022 to June 2023. Women completed two DCEs on PrEP products and PrEP delivery. At enrolment and month 1, participants completed the DCE about PrEP products with 16 randomly assorted choice sets assessing product form and dosing, dose forgiveness, drug reversibility, weight change and antiretroviral or immune-based mechanism attributes. At month 3, participants completed the DCE about PrEP delivery evaluating preferences related to location to collect doses, packaging, product storage, type of HIV test and costs. Preference weights (PW) were estimated with a hierarchical Bayesian model; higher positive numbers indicate greater preference for an attribute. Importance scores compare relative importance across the five attributes; higher scores indicate greater importance. RESULTS: Two thousand eight hundred and forty-seven women completed enrolment and month 1 DCEs; the median age was 24 years (range: 16-30) and 92.8% initiated daily oral PrEP. Product form and dosing was the most importa...