Tumor Metastasis: Mechanistic Insights and Therapeutic Intervention

作者：Lin Tang, Shao‐Cong Peng, Xiao‐Wan Zhuang, Yan He, Yuxiang Song, Hao Nie, Can‐Can Zheng, Zhenyu Pan, Alfred K. Lam, Ming‐Liang He, Xingyuan Shi, Bin Li, Wenwen Xu · 发表于：MedComm – Oncology · 年份：2025 · DOI：10.1002/mog2.70012 · 被引用次数：10 · 研究领域：Peptidase Inhibition and Analysis、Protein Degradation and Inhibitors、Cancer Mechanisms and Therapy

ABSTRACT Metastasis remains a leading cause of cancer‐related deaths, defined by a complex, multi‐step process in which tumor cells spread and form secondary growths in distant tissues. Despite substantial progress in understanding metastasis, the molecular mechanisms driving this process and the development of effective therapies remain incompletely understood. Elucidating the molecular pathways governing metastasis is essential for the discovery of innovative therapeutic targets. The rapid advancements in sequencing technologies and the expansion of biological databases have significantly deepened our understanding of the molecular drivers of metastasis and associated drug resistance. This review focuses on the molecular drivers of metastasis, particularly the roles of genetic mutations, epigenetic changes, and post‐translational modifications in metastasis progression. We also examine how the tumor microenvironment influences metastatic behavior and explore emerging therapeutic strategies, including targeted therapies and immunotherapies. Finally, we discuss future research directions, stressing the importance of novel treatment approaches and personalized strategies to overcome metastasis and improve patient outcomes. By integrating contemporary insights into the molecular basis of metastasis and therapeutic innovation, this review provides a comprehensive framework to guide future research and clinical advancements in metastatic cancer.