Open versus laparoscopic oncologic resection for gallbladder cancer after index cholecystectomy: international multicenter comparative study

作者：Łukasz Masior, Maciej Krasnodębski, Emilia Kruk, Martín de Santibañes, Pedro Uad, J. M. Ramos, Michał Pędziwiatr, Wojciech Serednicki, Gilton Marques Fonseca, Paulo Herman, R. Sutcliffe, Ravi Marudanayagam, Alessandro Parente, Arianeb Mehrabi, Ali Ramouz, P. Lodge, Keyur B. Shah, Hauke Lang, C. Scholz, Ganesh Gunasekaran, Nazanin Khajoueinejad, Samantha Troob, Marek Krawczyk, Michał Grąt · 发表于：Langenbeck s Archives of Surgery · 年份：2025 · DOI：10.1007/s00423-025-03643-6 · 被引用次数：3 · 研究领域：Cholangiocarcinoma and Gallbladder Cancer Studies、Gallbladder and Bile Duct Disorders、Hepatocellular Carcinoma Treatment and Prognosis

BACKGROUND: Liver resection and lymphadenectomy is a standard procedure in patients with incidental gallbladder cancer. Data regarding laparoscopic approach in this setting are scarce. The aim of this study was to compare laparoscopic and open approach in this population. METHODS: This was a multicenter retrospective study including 177 patients. The primary outcome measure was overall survival (OS). The secondary outcomes measures were recurrence-free survival (RFS), lymph node yield, operative time, postoperative complications and length of hospital stay. RESULTS: Surgery was laparoscopic in 60 (33.9%), including 18 conversions (30.0%). By intention to treat analysis, 3 and 5 year OS were 72.1% and 51.8% after laparoscopic surgery compared to 62.8% and 36.2% after open surgery (p = 0.201). 3- and 5-year RFS were 29.1% and 19.4% after laparoscopic surgery and 28.7% and 19.1% after open surgery (p = 0.697). Severe (grade ≥ 3 ) complications (p = 0.032) and Comprehensive Complication Index (CCI; p = 0.027) were both significantly higher after laparoscopic surgery (p = 0.032), although length of hospital stay was significantly shorter after laparoscopic procedures both on intention-to-treat (median 6 vs. 8 days; p = 0.004) and per protocol analysis (median 6 vs. 8 days; p = 0.004). CONCLUSIONS: Laparoscopic approach is feasible in patients with gallbladder cancer and may shorten the duration of hospital stay. SYNOPSIS: This retrospective cohort study suggests that laparoscopic ...