Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

作者：Abu Mohammad Syed, Alexander Karius, Jin Ma, Ping-yuan Wang, Paul M. Hwang · 发表于：Physiology · 年份：2025 · DOI：10.1152/physiol.00056.2024 · 被引用次数：28 · 研究领域：Fibromyalgia and Chronic Fatigue Syndrome Research、Long-Term Effects of COVID-19、Mitochondrial Function and Pathology

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disorder of unclear etiology that affects many individuals worldwide. One of its hallmark symptoms is prolonged fatigue following exertion, a feature also observed in long COVID, suggesting an underlying dysfunction in energy production in both conditions. Here, mitochondrial dysfunction and its potential pathogenetic role in these disorders are reviewed.