Association Between Depressive Symptoms and Self-Reported Physical Activity in Persons With Knee Osteoarthritis

作者：Alan M. Rathbun, Alice S. Ryan, Michelle Shardell, Yu Dong, Brock A. Beamer, Mark Luborsky, Marc C. Hochberg · 发表于：The Journal of Rheumatology · 年份：2025 · DOI：10.3899/jrheum.2024-0940 · 被引用次数：2 · 研究领域：Osteoarthritis Treatment and Mechanisms、Total Knee Arthroplasty Outcomes、Mindfulness and Compassion Interventions

Objective Depressive symptoms are common in patients with knee osteoarthritis (KOA) and reduce energy, motivation, and movement; thus, declines in physical activity (PA) could worsen as clinical disease progresses. The objective was to evaluate the longitudinal relationship between depressive symptoms and self-reported PA over time among persons with KOA. Methods The sample included Osteoarthritis Initiative participants (N = 2602) with radiographic disease (Kellgren-Lawrence grade ≥ 2). Depressive symptoms were measured using the Center for Epidemiologic Studies Depression Scale (CES-D; score ≥ 16) at baseline and first 3 follow-up visits. Self-reported PA was assessed with the Physical Activity Scale for the Elderly (PASE) at the first 4 follow-up visits. Marginal structural models controlling for time-invariant and time-varying confounders evaluated the longitudinal relationship between depressive symptoms and PASE z scores. Results Depressive symptoms were associated with lower PA (β −0.09; 95% CI −0.20 to 0.01) over time, but the relationship was not statistically significant. When including depressive symptoms-by-time interactions, the relationship was nonlinear from the first to fourth follow-up visit: visit 1 = −0.18 (95% CI −0.33 to −0.02), visit 2 = −0.05 (95% CI −0.22 to 0.11), visit 3 = −0.01 (95% CI −0.19 to 0.16), and visit 4 = −0.11 (95% CI −0.29 to 0.08). However, the interaction terms were not statistically significant. Conclusion Depressive symptoms may cont...