The role of mitochondrial biogenesis, mitochondrial dynamics and mitophagy in gastrointestinal tumors

作者：Yi‐Hong Liu, Hao Wang, Shen Zhang, Na Peng, Shuangshuang Hai, Haibo Zhao, Jingwei Liu, Weixin Liu · 发表于：Cancer Cell International · 年份：2025 · DOI：10.1186/s12935-025-03685-2 · 被引用次数：12 · 研究领域：Cancer, Hypoxia, and Metabolism、Mitochondrial Function and Pathology、RNA modifications and cancer

Gastrointestinal tumors remain the leading causes of cancer-related deaths, and their morbidity and mortality remain high, which imposes a great socio-economic burden globally. Mitochondrial homeostasis depend on proper function and interaction of mitochondrial biogenesis, mitochondrial dynamics (fission and fusion) and mitophagy. Recent studies have demonstrated close implication of mitochondrial homeostasis in gastrointestinal tumorigenesis and development. In this review, we summarized the research progress on gastrointestinal tumors and mitochondrial quality control, as well as the underlying molecular mechanisms. It is anticipated that the comprehensive understanding of mitochondrial homeostasis in gastrointestinal carcinogenesis would benefit the application of mitochondria-targeted therapies for gastrointestinal tumors in future.