Dysregulation of neutrophil in sepsis: recent insights and advances

作者：Ji Zhang, Yuwen Shao, Jingyi Wu, Jing Zhang, Xiangsheng Xiong, Jingjing Mao, Yunwei Wei, Changhong Miao, Hao Zhang · 发表于：Cell Communication and Signaling · 年份：2025 · DOI：10.1186/s12964-025-02098-y · 被引用次数：50 · 研究领域：Neutrophil, Myeloperoxidase and Oxidative Mechanisms、Sepsis Diagnosis and Treatment、Blood disorders and treatments

Sepsis remains the leading cause of death in intensive care units. Despite newer antimicrobial and supportive therapies, specific treatments are still lacking. Neutrophils are pivotal components of the effector phase of the host immune defense against pathogens and play a crucial role in the control of infections under normal circumstances. In addition to its anti-infective effects, the dysregulation and overactivation of neutrophils may lead to severe inflammation or tissue damage and are potential mechanisms for poor prognosis in sepsis. This review focuses on recent advancements in the understanding of the functional status of neutrophils across various pathological stages of sepsis to explore the mechanisms by which neutrophils participate in sepsis progression and provide insights for the treatment of sepsis by targeting neutrophils.