Dynamic Visualization of Computer-Aided Peptide Design for Cancer Therapeutics

作者：Dan Hou, Haobin Zhou, Yuting Tang, Ziyuan Liu, Lin Su, Junkai Guo, Janak Lal Pathak, Lihong Wu · 发表于：Drug Design Development and Therapy · 年份：2025 · DOI：10.2147/dddt.s497126 · 被引用次数：9 · 研究领域：vaccines and immunoinformatics approaches、Antimicrobial Peptides and Activities、Immunotherapy and Immune Responses

Purpose: Cancer stands as a significant global public health concern, with traditional therapies potentially yielding severe side effects. Peptide-based cancer therapy is increasingly employed for diseases like cancer due to its advantages of excellent targeting, biocompatibility, and convenient synthesis. With advancements in computer technology and bioinformatics, rational design strategies based on computer technology have been employed to develop more cost-effective and potent anticancer peptides (ACPs). This study aims to explore the current status, hotspots, and future trends in the field of computer-aided design of peptides for cancer treatment through a bibliometric analysis. Methods: A total of 1547 relevant publications published from 2006 to 2024 were collected from the Web of Science Core Collection. Bibliometric analysis was conducted using tools like CiteSpace, VOSviewer, Bibliometrix, Origin, and an online bibliometric platform. Results: The research in this field has shown a steady growth trend, with the United States and China making the most significant contributions. Currently, ACP research mainly focuses on cell-penetrating peptides related to drug delivery, which are expected to become future research hotspots. Beyond that, peptide vaccines associated with immunotherapy are also worthy of attention. In addition, molecular dynamics simulation and molecular docking are currently popular research methods. At the same time, deep learning is the emerging keywo...