Association of 25-hydroxyvitamin D with Parkinson’s disease based on the results from the NHANES 2007 to 2018 and Mendelian randomization analysis

作者：Xu Yan, Jie Peng, Xiguo Zhou, Yue-Xin Huang, Guanzhen Zhong, Zhiwei Xia · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-87120-6 · 被引用次数：5 · 研究领域：Vitamin D Research Studies、Folate and B Vitamins Research、Nutritional Studies and Diet

An abundance of observational researches had suggested that vitamin D insufficient was related to Parkinson's disease (PD) risk. However, their relationships were debatable and the causality remains uncertain. We intended to evaluate the association between 25-hydroxyvitamin D [25(OH)D] and Parkinson's disease (PD) risk using NHANES data (2007-2018) and Mendelian randomization (MR) analyses with the genome-wide association study (GWAS) summary data. Demographic characteristics and multivariable-adjusted logistic regression were conducted to assess the relationship between the serum 25(OH)D levels and risk of PD prevalence by utilizing NHANES database. Besides, a two-sample MR analysis was applied to evaluate the causal association between serum 25(OH)D levels and PD risk. The main analysis was conducted by citing the inverse-variance-weighted (IVW) approach, while additional MR approaches and multiple sensitivity analysis were cited to evaluate the robustness and pleiotropy for the discoveries. In total, 30,796 adults from NHANES 2007-2018 were selected for the present research. As a result, 1.1% participants with PD (mean age: 61.9 ± 15.5 years), while 68.5% reported vitamin D insufficient. Compared with participants without PD, those with PD had a greater level of 25(OH)D (P < 0.01). However, after adjusted for demographic characteristics and comorbid factors, this association was not observed. Furthermore, no potential causal relationships between the serum level of 25(OH)...