3D-printed CoSi/PCL composite scaffold with NIR-II photothermal ability and enhanced adipogenic activity for breast reconstruction after mastectomy

作者：Jupei Zhang, Hangbin Xia, Xuerui Zhou, Zhaoxu Meng, Qishu Jin, Dongmin Chen, Xiaojuan Xia, Yiren Jiao, Jiang Chang, Zhihong Dong, Zhen Zeng, Hongshi Ma, Chen Yang · 发表于：Materials Today Bio · 年份：2025 · DOI：10.1016/j.mtbio.2025.101577 · 被引用次数：10 · 研究领域：Bone Tissue Engineering Materials、Reconstructive Surgery and Microvascular Techniques、Tissue Engineering and Regenerative Medicine

, CoSi) to form a multi-functional CoSi/PCL composite scaffold through 3D printing technology. The scaffold exhibits a controllable shape with designed macroporous architecture. Its photothermal performances are well presented in both near-infrared (NIR) I and NIR-II regions, enabling effective tumor ablation with minimal side effects. Additionally, the release of bioactive silicate and cobalt ions promotes adipogenesis and angiogenesis, thereby enhancing the integration of the scaffold with surrounding tissues. This approach offers a promising strategy for combining tumor therapy with breast reconstruction, providing a clinically relevant solution for post-mastectomy patients.