Clinical correlation between intestinal flora profiles and the incidence of postmenopausal osteoporosis

作者：Cuifeng Zhu, Yuan Zhang, Yi Pan, Yi Pan, Zhentian Zhang, Yan Liu, Xiuping Lin, Jinchuan Cai, Zhuang Xiong, Yong Pan, Yong Pan, Hezhongrong Nie · 发表于：Gynecological Endocrinology · 年份：2025 · DOI：10.1080/09513590.2025.2465587 · 被引用次数：10 · 研究领域：Gut microbiota and health、Bone health and osteoporosis research、Bone Metabolism and Diseases

Purpose This study aimed to explore the characteristics of intestinal microflora polymorphism in postmenopausal women, and to determine the pathophysiological changes of gene polymorphism of intestinal flora and bone metabolism in postmenopausal osteoporosis (PMOP) patients.Methods A total of 104 postmenopausal women with PMOP or normal bone density were included. Lifestyle, hip T-score, bone metabolism indexes (25(OH)D, PTH, β-CTX, PINP), intestinal mucous membrane barrier function (diamine oxidase, D-lactic acid, LPS), gene polymorphisms, and characteristics of gut microbiota were examined.Results Women with PMOP had reduced physical activity, less dietary protein and calcium intake, lower levels of 25(OH)D, hip T-score, and BMD, but PMOP group had increased total energy and fat intake, and higher levels of PTH, β-CTX, diamine oxidase, D-lactic acid, and LPS (p < .05 for all), as compared with normal subjects. Analyses of the α- and β-diversity of fecal microbiota indicated remarkably differences in postmenopausal women with or without PMOP. In details, individuals with PMOP had increased abundances of some genera (e.g. Roseburia and Bacteroides), but decreased abundances of some genera (e.g. Streptococcus and Dorea). Furthermore, use of a random forest model based on differential abundant taxa and ROC analysis could efficiently identify women with PMOP in the present cohort (AUC = 0.93).Conclusion The incidence of PMOP was closely associated with fecal microbial compositio...