Effects of gastrointestinal symptoms on the efficacy of washed microbiota transplantation in patients with autism

作者：Dongxia Hu, Cheng‐Kai Lu, X.C. Si, Qingting Wu, Li‐Hao Wu, Haojie Zhong, Xing‐Xiang He · 发表于：Frontiers in Pediatrics · 年份：2025 · DOI：10.3389/fped.2025.1528167 · 被引用次数：10 · 研究领域：Gastrointestinal motility and disorders、Clostridium difficile and Clostridium perfringens research、Gut microbiota and health

Objective Washed microbiota transplantation (WMT) has emerged as a promising therapeutic strategy for autism spectrum disorder (ASD), though the factors that influence its efficacy remain poorly understood. This study explores the impact of gastrointestinal (GI) symptoms on the effectiveness of WMT in ASD. Methods Clinical data encompassing ASD symptoms, GI disturbances, and sleep disorders were collected from patients with ASD undergoing WMT. The therapeutic impact of WMT and the contributing factors to its efficacy were assessed. Results WMT significantly reduced scores on the Aberrant Behavior Checklist (ABC), Childhood Autism Rating Scale (CARS), and Sleep Disturbance Scale for Children (SDSC), alongside a significant reduction in the incidence of constipation, abnormal stool forms, and diarrhea (all p < 0.05). After six courses of WMT, substantial reductions were observed in ABC, CARS, and SDSC scores, with increased treatment courses correlating with greater improvement ( p < 0.05). Multiple linear regression analysis revealed that WMT efficacy was enhanced in patients with pre-existing GI symptoms (diarrhea: β = 0.119, p < 0.001; abnormal stool form: β = 0.201, p < 0.001) and those receiving a higher number of treatment courses ( β = 0.116, p < 0.001). Additionally, the analysis indicated that treatment outcomes were more favorable in patients who had not undergone adjunct interventions ( β = −0.041, p = 0.002), had a longer disease d...