Mass cytometric analysis of circulating monocyte subsets in a murine model of diabetic gastroparesis

作者：Shefaa AlAsfoor, Erik Jessen, Suraj R. Pullapantula, Jennifer R. Voisin, Linda C. Hsi, Kevin D. Pavelko, Samera Farwana, Jack A. Patraw, Xin-yi Chai, Sihan Ji, Michael Strausbauch, Gianluca Cipriani, Lai Wei, David R. Linden, Ruixue Hou, R Myers, Yogesh Bhattarai, Jill Wykosky, Alan J. Burns, Surendra Dasari, Gianrico Farrugia, Madhusudan Grover · 发表于：American Journal of Physiology-Gastrointestinal and Liver Physiology · 年份：2025 · DOI：10.1152/ajpgi.00229.2024 · 被引用次数：2 · 研究领域：Immune cells in cancer、Gastrointestinal motility and disorders、Gut microbiota and health

Using 32 immune cell surface markers, we identified 23 monocyte clusters in murine blood. Diabetic gastroparesis was associated with a significant decrease in two circulating classical monocyte-like clusters and an upregulation of the Ccr2-Ccl2 axis in the gastric muscularis propria, suggesting increased tissue monocyte migration. This study offers new targets by pointing to a possible role for two classical monocyte subsets connected to the Ccr2- Ccl2 axis.