Effects of otolaryngological diseases on sleep quality, anxiety, and depression: a multicenter observational study

作者：Chen Qi, Q Wang, Mi Wang, Linbin Cai, M. Shen, Kan Liu, Jin-Long Zhu, Cong Wang, Qibing Chen, Ting‐Ting Wu, Shui‐Hong Zhou, Jinhua Pan · 发表于：BMC Psychiatry · 年份：2025 · DOI：10.1186/s12888-025-06531-x · 被引用次数：1 · 研究领域：Voice and Speech Disorders、Temporomandibular Joint Disorders、Obstructive Sleep Apnea Research

BACKGROUND: The impact of otolaryngological diseases on sleep quality, anxiety, and depression has garnered significant attention. However, research has primarily focused on unveiling the effects of only one or two specific diseases, without analyzing the impact of multiple concurrent diseases. Furthermore, investigation into the interaction mechanisms among these factors has been lacking. OBJECTIVES: This study reveals the effects of different otolaryngological diseases on sleep quality, anxiety, and depression, and investigates their interaction mechanisms. METHODS: In total, 2,080 patients with otolaryngological diseases were recruited from six centers in mainland China. Data on sociodemographics, history of smoking and alcohol consumption, diagnosis, anxiety, depression, and sleep quality were collected through hospital information system queries and questionnaires. We uncovered the psychological status and sleep quality of otolaryngology outpatients with different diseases and revealed the interaction mechanisms between these diseases and anxiety, depression, and sleep quality. Multivariable polynomial linear regression models explored the impact of different otolaryngological diseases on anxiety, depression and sleep quality, and mediation analysis explored the interaction mechanisms. RESULTS: Chronic laryngitis, eustachian tube disorders, laryngeal swelling, laryngopharyngeal reflux, neck lymphatic inflammation, snoring, sudden deafness, tinnitus, nasopharyngeal lesion...